Author

M. S. Abdel-Hakeem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Mathew· 2 shared H. Huang· 2 shared J. R. Giles· 2 shared S. Manne· 2 shared Y. J. Huang· 2 shared A. C. Huang· 1 shared A. E. Baxter· 1 shared C. K. Garcia· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

D. Mathew

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

J. C. Beltra, M. S. Abdel-Hakeem, S. Manne, Z. Zhang, H. Huang, M. Kurachi, L. Su, L. Picton, Y. Muroyama, V. Casella, Y. J. Huang, J. R. Giles, D. Mathew, J. Belman, M. Klapholz, , J. E. Wherry

This study shows that enhancing STAT5a activation in exhausted CD8 T cells rewires their epigenetic state to become a hybrid durable effector-like population with improved tumor control.

bioRxiv · Oct 3, 2022 · PreprintImmunology

Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates

J. R. Giles, S. F. Ngiow, S. Manne, A. E. Baxter, O. Khan, P. Wang, R. Staupe, M. S. Abdel-Hakeem, H. Huang, D. Mathew, M. M. Painter, J. E. Wu, Y. J. Huang, R. Goel, E. J. Wherry

This study maps transcriptional and epigenetic changes in CD8 T cell differentiation using scRNA-seq and scATAC-seq, revealing shared biological circuits across effector, memory, and exhausted cell fates.

bioRxiv · Mar 27, 2022 · PreprintImmunology