Author

Y. J. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Research Focus:gene regulatory network inference· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

J. R. Giles· 5 shared S. Manne· 5 shared A. E. Baxter· 4 shared D. Mathew· 4 shared E. J. Wherry· 4 shared J. E. Wu· 4 shared A. C. Huang· 3 shared H. Huang· 3 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersImmunology

J. R. Giles

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

J. E. Wu, S. Manne, S. F. Ngiow, A. E. Baxter, H. Huang, E. Freilich, M. L. Clark, J. H. Lee, Z. Chen, O. Khan, R. P. Staupe, Y. J. Huang, J. Shi, J. R. Giles, E. J. Wherry

The paper establishes an in vitro model of CD8 T cell exhaustion and uses CRISPR screening to identify BHLHE40 as a regulator of T cell exhaustion differentiation.

bioRxiv · Apr 17, 2023 · PreprintImmunology

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

J. C. Beltra, M. S. Abdel-Hakeem, S. Manne, Z. Zhang, H. Huang, M. Kurachi, L. Su, L. Picton, Y. Muroyama, V. Casella, Y. J. Huang, J. R. Giles, D. Mathew, J. Belman, M. Klapholz, , J. E. Wherry

This study shows that enhancing STAT5a activation in exhausted CD8 T cells rewires their epigenetic state to become a hybrid durable effector-like population with improved tumor control.

bioRxiv · Oct 3, 2022 · PreprintImmunology

Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates

J. R. Giles, S. F. Ngiow, S. Manne, A. E. Baxter, O. Khan, P. Wang, R. Staupe, M. S. Abdel-Hakeem, H. Huang, D. Mathew, M. M. Painter, J. E. Wu, Y. J. Huang, R. Goel, E. J. Wherry

This study maps transcriptional and epigenetic changes in CD8 T cell differentiation using scRNA-seq and scATAC-seq, revealing shared biological circuits across effector, memory, and exhausted cell fates.

bioRxiv · Mar 27, 2022 · PreprintImmunology

AlphaFold Models of Small Proteins Rival the Accuracy of Solution NMR Structures

R. Tejero, Y. J. Huang, T. Ramelot, G. T. Montelione

The paper evaluates AlphaFold models of small proteins against experimental NMR and X-ray structures, finding they match or exceed NMR accuracy.

bioRxiv · Mar 9, 2022Biochemistry

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

S. A. Apostolidis, A. Sarkar, H. M. Giannini, R. R. Goel, D. Mathew, A. Suzuki, A. E. Baxter, A. R. Greenplate, C. Alanio, M. Abdel-Hakeem, D. A. Oldridge, J. R. Giles, J. E. Wu, Z. Chen, Y. J. Huang, , E. J. Wherry

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

Frontiers in Immunology · Mar 3, 2022Peer-reviewedImmunology

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

D. Mathew, J. R. Giles, A. E. Baxter, A. R. Greenplate, J. E. Wu, C. Alanio, D. A. Oldridge, L. Kuri-Cervantes, M. B. Pampena, K. D'Andrea, S. Manne, Z. Chen, Y. J. Huang, J. P. Reilly, A. R. Weisman, , E. J. Wherry

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

bioRxiv · May 20, 2020Immunology

Cell non-autonomous interactions during non-immune stromal progression in the breast tumor microenvironment

R. Utama, A. Bastian, N. Sadagopan, Y. Jin, E. Antoniou, Q. Gao, Y. J. Huang, S. Pillai, P. P. Lee, G. S. Atwal

The paper analyzes non-immune stromal gene expression in breast tumors across different stages and identifies gene expression patterns associated with cancer progression and clinical outcomes.

bioRxiv · Feb 4, 2019 · PreprintCancer Biology