Author

S. Manne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 11

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 9 Organism:human· 7 Approach:experimental assay· 6 Research Focus:differential expression· 5 Research Focus:gene regulatory network inference· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Approach:deep learning· 4

Frequent Co-Authors

E. J. Wherry· 10 shared J. R. Giles· 8 shared A. E. Baxter· 6 shared J. E. Wu· 6 shared L. A. Vella· 6 shared A. R. Greenplate· 5 shared D. Mathew· 5 shared Y. J. Huang· 5 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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10 shared papersImmunology

E. J. Wherry

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Author profile →

11 papers

Recent·Most cited

In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

J. E. Wu, S. Manne, S. F. Ngiow, A. E. Baxter, H. Huang, E. Freilich, M. L. Clark, J. H. Lee, Z. Chen, O. Khan, R. P. Staupe, Y. J. Huang, J. Shi, J. R. Giles, E. J. Wherry

The paper establishes an in vitro model of CD8 T cell exhaustion and uses CRISPR screening to identify BHLHE40 as a regulator of T cell exhaustion differentiation.

bioRxiv · Apr 17, 2023 · PreprintImmunology

Distinct Heterogeneity in the Naive T cell Compartments of Children and Adults

C. E. Gustafson, Z. Thomson, Z. He, E. Swanson, K. Henderson, M.-P. L. Pebworth, L. Y. Okada, A. T. Heubeck, C. R. Roll, V. Hernandez, M. D. Weiss, P. C. Genge, J. Reading, J. R. Giles, S. Manne, , P. J. Skene

The study identifies age-related differences in naive T cell compartments between children and adults, showing distinct molecular reprogramming in CD4 and CD8 subsets.

bioRxiv · Oct 4, 2022 · PreprintImmunology

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

J. C. Beltra, M. S. Abdel-Hakeem, S. Manne, Z. Zhang, H. Huang, M. Kurachi, L. Su, L. Picton, Y. Muroyama, V. Casella, Y. J. Huang, J. R. Giles, D. Mathew, J. Belman, M. Klapholz, , J. E. Wherry

This study shows that enhancing STAT5a activation in exhausted CD8 T cells rewires their epigenetic state to become a hybrid durable effector-like population with improved tumor control.

bioRxiv · Oct 3, 2022 · PreprintImmunology

Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancer.

Y. Muroyama, S. Manne, N. Wellhausen, D. A. Oldridge, A. R. Greenplate, L. Chilukuri, D. Mathew, C. Xu, R. S. Herati, S. L. Berger, A. C. Huang, C. H. June, D. Zamarin, C. F. Friedman, E. J. Wherry

The paper identifies a CD8 T cell intrinsic DNA damage response linked to clinical response to PD-1 blockade in uterine cancer using high-dimensional single-cell analysis.

bioRxiv · Apr 16, 2022 · PreprintImmunology

Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates

J. R. Giles, S. F. Ngiow, S. Manne, A. E. Baxter, O. Khan, P. Wang, R. Staupe, M. S. Abdel-Hakeem, H. Huang, D. Mathew, M. M. Painter, J. E. Wu, Y. J. Huang, R. Goel, E. J. Wherry

This study maps transcriptional and epigenetic changes in CD8 T cell differentiation using scRNA-seq and scATAC-seq, revealing shared biological circuits across effector, memory, and exhausted cell fates.

bioRxiv · Mar 27, 2022 · PreprintImmunology

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

S. A. Apostolidis, A. Sarkar, H. M. Giannini, R. R. Goel, D. Mathew, A. Suzuki, A. E. Baxter, A. R. Greenplate, C. Alanio, M. Abdel-Hakeem, D. A. Oldridge, J. R. Giles, J. E. Wu, Z. Chen, Y. J. Huang, , E. J. Wherry

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

Frontiers in Immunology · Mar 3, 2022Peer-reviewedImmunology

The identity of human tissue-emigrant CD8+ T cells

M. Buggert, L. A. Vella, S. Nguyen, V. Wu, T. Sekine, A. Perez-Potti, C. R. Maldini, S. Manne, S. Darko, A. Ransier, L. Kuri-Cervantes, A. Sada Japp, I. Bukh Brody, M. A. Ivarsson, L. Hertwig, , M. R. Betts

The paper characterizes tissue-emigrant CD8+ T cells in humans and non-human primates, revealing distinct migratory behaviors and clonal dynamics.

bioRxiv · Aug 11, 2020Immunology

In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer

Z. Chen, E. Arai, O. Khan, Z. Zhang, S. F. Ngiow, Y. He, H. Huang, S. Manne, Z. Cao, A. E. Baxter, Z. Cai, E. Freilich, M. A. Ali, J. R. Giles, J. E. Wu, , J. Shi

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

bioRxiv · May 20, 2020 · PreprintImmunology

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

D. Mathew, J. R. Giles, A. E. Baxter, A. R. Greenplate, J. E. Wu, C. Alanio, D. A. Oldridge, L. Kuri-Cervantes, M. B. Pampena, K. D'Andrea, S. Manne, Z. Chen, Y. J. Huang, J. P. Reilly, A. R. Weisman, , E. J. Wherry

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

bioRxiv · May 20, 2020Immunology

Chronic viral infection promotes early germinal center exit of B cells and impaired antibody development.

R. P. Staupe, L. A. Vella, S. Manne, J. R. Giles, W. Meng, R. S. Herati, O. Khan, J. E. Wu, A. E. Baxter, E. T. Luning Prak, E. J. Wherry

This study shows chronic viral infection disrupts GC B cell fate decisions, leading to early exit and impaired antibody development.

bioRxiv · Nov 21, 2019 · PreprintImmunology

Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways

R. S. Herati, L. V. Silva, L. A. Vella, A. Muselman, C. Alanio, B. Bengsch, R. Kurupati, S. Kannan, S. Manne, A. Kossenkov, D. Canaday, S. Doyle, H. Ertl, K. Schmader, E. J. Wherry

The paper uses transcriptional profiling to show that vaccine-induced ICOS+CD38+ cTfh cells in elderly show inflammation-related gene signatures and age-associated biological changes.

bioRxiv · Jul 24, 2019 · PreprintImmunology