Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia
F. Sciarretta, F. Zaccaria, A. Ninni, V. Ceci, R. Turchi, S. Apolloni, V. Chiurchiu, M. Tiberi, N. D'Ambrosi, S. Pedretti, N. Mitro, K. AQUILANO, D. Lettieri Barbato, I. Della Valle, M. Milani
This study shows that frataxin deficiency in microglia shifts metabolism to glucose catabolism, causing inflammation, which is mitigated by butyrate treatment.
bioRxiv · Oct 18, 2023Physiology