An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.
Y. Yao, R. U. Kadam, C.-C. D. Lee, J. L. Woehl, N. C. Wu, X. Zhu, S. Kitamura, I. A. Wilson, D. W. Wolan
This paper identifies a small-molecule inhibitor of influenza A HA stem fusion using a fluorescence polarization screen and validates its antiviral activity against multiple H1N1 and H5N1 strains.
bioRxiv · Apr 2, 2020Biophysics