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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
13 papers
Recent·Most cited
H. Lv, Q. W. Teo, C.-C. D. Lee, W. Liang, D. Choi, K. J. Mao, R. Bruzzone, I. A. Wilson, N. C. Wu, C. K. Mok
This study examines how immune history affects antibody responses to influenza H1N1 hemagglutinin and neuraminidase in mice, finding that HA responses are more restricted by prior infection than NA responses.
bioRxiv · Apr 17, 2024Immunology
C. Dacon, C. Tucker, L. Peng, C.-C. D. Lee, T.-H. Lin, M. Yuan, Y. Cong, L. Wang, L. Purser, J. K. Williams, C.-W. Pyo, I. Kosik, Z. Hu, M. Zhao, D. Mohan, , J. Tan
The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.
bioRxiv · Apr 11, 2022Immunology
M. Yuan, D. Huang, C.-C. D. Lee, N. C. Wu, A. M. Jackson, X. Zhu, H. Liu, L. Peng, M. J. van Gils, R. W. Sanders, D. R. Burton, S. M. Reincke, H. Prüss, J. Kreye, D. Nemazee, , I. A. Wilson
The paper examines how mutations at E484 and K417 in SARS-CoV-2 variants affect neutralizing antibodies, showing reduced efficacy against certain antibody families but not others.
bioRxiv · Feb 16, 2021Microbiology
H. Liu, M. Yuan, D. Huang, S. Bangaru, C.-C. D. Lee, L. Peng, X. Zhu, D. Nemazee, M. J. van Gils, R. W. Sanders, H.-C. Kornau, S. M. Reincke, H. Pruss, J. Kreye, N. C. Wu, , I. A. Wilson
This study shows that combining cross-neutralizing antibodies CV38-142 and COVA1-16 enhances neutralization of SARS-CoV-2 and SARS-CoV pseudoviruses.
bioRxiv · Feb 11, 2021Microbiology
M. Qiang, P. Ma, Y. Li, H. Liu, A. Harding, C. Min, L. Liu, M. Yuan, Q. Ji, P. Tao, X. Shi, Z. Li, F. Wang, Y. Zhang, N. C. Wu, , R. A. Lerner
The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.
bioRxiv · Nov 6, 2020 · PreprintMicrobiology
H. Lv, R. T. Y. So, M. Yuan, H. Liu, C.-C. D. Lee, G. K. Yip, W. W. Ng, I. A. Wilson, J. S. M. Peiris, N. C. Wu, C. K. P. Mok
This study shows that prior exposure to one Sarbecovirus strain biases antibody response to a subsequent, antigenically distinct strain, suggesting antigenic imprinting affects immunity to SARS-CoV-2.
bioRxiv · Oct 14, 2020 · PreprintImmunology
N. C. Wu, M. Yuan, S. Bangaru, D. Huang, X. Zhu, C.-C. D. Lee, H. L. Turner, L. Peng, L. Yang, D. Nemazee, A. B. Ward, I. A. Wilson
This study identifies a single amino acid mutation that determines the difference in neutralization ability of a cross-reactive antibody between SARS-CoV-2 and SARS-CoV.
bioRxiv · Sep 21, 2020Microbiology
J. Kreye, S. M. Reincke, H.-C. Kornau, E. Sanchez-Sendin, V. M. Corman, H. Liu, M. Yuan, N. C. Wu, X. Zhu, C.-C. D. Lee, J. Trimpert, M. Hoeltje, K. Dietert, L. Stoeffler, N. von Wardenburg, , N. Osterrieder
This study identifies a potent SARS-CoV-2 neutralizing antibody that protects hamsters from infection and lung damage.
bioRxiv · Aug 15, 2020Immunology
H. Liu, N. C. Wu, M. Yuan, S. Bangaru, J. L. Torres, T. G. Caniels, J. van Schooten, X. Zhu, C.-C. D. Lee, P. J. M. Brouwer, M. J. van Gils, R. W. Sanders, A. B. Ward, I. A. Wilson
The paper identifies a SARS-CoV-2 antibody that cross-neutralizes SARS-CoV by binding a conserved epitope and relies on avidity for neutralization.
bioRxiv · Aug 2, 2020Microbiology
N. C. Wu, M. Yuan, H. Liu, C.-C. D. Lee, X. Zhu, S. Bangaru, J. L. Torres, T. G. Caniels, P. J. M. Brouwer, M. J. van Gils, R. W. Sanders, A. B. Ward, I. A. Wilson
This study identifies an alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 RBD, showing that longer CDR H3 can bind with different angles and interactions.
bioRxiv · Jul 26, 2020Microbiology
M. Yuan, H. Liu, N. C. Wu, C.-C. D. Lee, X. Zhu, F. Zhao, D. Huang, W. Yu, Y. Hua, H. Tien, T. F. Rogers, E. Landais, D. Sok, J. G. Jardine, D. R. Burton, I. A. Wilson
The paper identifies IGHV3-53 as a common VH gene for SARS-CoV-2 neutralizing antibodies and determines its structural basis for binding the RBD.
bioRxiv · Jun 8, 2020Microbiology
Y. Yao, R. U. Kadam, C.-C. D. Lee, J. L. Woehl, N. C. Wu, X. Zhu, S. Kitamura, I. A. Wilson, D. W. Wolan
This paper identifies a small-molecule inhibitor of influenza A HA stem fusion using a fluorescence polarization screen and validates its antiviral activity against multiple H1N1 and H5N1 strains.
bioRxiv · Apr 2, 2020Biophysics
M. Yuan, N. C. Wu, X. Zhu, C.-C. D. Lee, R. T. Y. So, H. Lv, C. K. P. Mok, I. A. Wilson
Structural study of a cross-reactive SARS antibody reveals a conserved epitope on the SARS-CoV-2 receptor-binding domain.
bioRxiv · Mar 13, 2020Microbiology