Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance
R. Unni, N. A. Andreani, M. Vallier, S. Heinzmann, J. Taubenheim, M. A. Guggeis, F. Tran, O. Vogler, S. Kuenzel, J.-B. Hövener, P. Rosenstiel, C. Kaleta, A. Dempfle, D. Unterweger, J. F. Baines
This study shows that E. coli evolves specific genetic and phenotypic traits in an inflamed gut, leading to antibiotic collateral sensitivity and potential therapeutic implications.
bioRxiv · Aug 16, 2023 · PreprintEvolutionary Biology