C. Kaleta

Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease

The paper examines the relationship between HK2 expression and inflammation severity in IBD patients using bulk transcriptome data and confirms findings at the cellular and protein levels.

Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance

This study shows that E. coli evolves specific genetic and phenotypic traits in an inflamed gut, leading to antibiotic collateral sensitivity and potential therapeutic implications.

Gut-associated functions are favored during microbiome assembly across C. elegans life

This study examines microbiome assembly dynamics in C. elegans, showing increased gut-associated functions and enrichment of specific bacterial genera over the host's lifetime.

Closely related Bacteroides of the murine intestinal microbiota affect each other's growth positively or negatively

The paper tests growth interactions between closely related Bacteroides strains from mice and finds both positive and negative effects, with growth promotion more common than inhibition.

The gene expression classifier ALLCatchR identifies B-precursor ALL subtypes and underlying developmental trajectories across age

ALLCatchR, a machine learning classifier, accurately assigns B-precursor ALL samples to molecular subtypes and identifies developmental trajectories using RNA-Seq data.

Bacterial colonizers of Nematostella vectensis are initially selected by the host before interactions between bacteria determine further succession

This study shows that host selection drives initial bacterial colonization in Nematostella vectensis, while subsequent succession depends on bacterial metabolic interactions.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.

Metabolic dissimilarity determines the establishment of cross-feeding interactions in bacteria

The study shows that metabolic dissimilarity between bacterial strains promotes cross-feeding interactions, as demonstrated through cocultivation experiments and in-silico analysis of gut microbiota.

CeMbio - The C. elegans microbiome resource

The paper introduces CeMbio, a simplified natural microbiota for C. elegans, enabling causal studies of host-microbiome interactions through a resource with culturable strains and associated tools.

The functional repertoire encoded within the native microbiome of the model nematode Caenorhabditis elegans

The paper analyzes the metabolic capabilities of the native microbiome of C. elegans and shows it can synthesize all essential nutrients for the nematode.

The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life

This study investigates how C. elegans responds to its native microbiome across development and adult life, identifying key molecular processes and regulatory mechanisms.