Author

R. V. Agafonov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Kern· 2 shared R. Otten· 2 shared A. Zorba· 1 shared F. Pontiggia· 1 shared G. E. Jara· 1 shared G. Kern· 1 shared M. A. Marti· 1 shared N. Kern· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

D. Kern

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2 papers

Recent·Most cited

BiophysicsbioRxivOct 3, 2023

Wide Transition-State Ensemble as Key Component for Enzyme Catalysis

G. E. Jara, F. Pontiggia, R. Otten…·D. Kern

The paper investigates the transition-state ensemble in adenylate kinase, finding a broad set of energetically equivalent configurations that support efficient enzyme catalysis.

DOI 10.7554/elife.93099

statistical modelprotein folding & dynamics

𝕏 PostBluesky

Cancer BiologybioRxivMar 21, 2018

Dynamics of human protein kinases linked to drug selectivity

D. Kern, W. Pitsawong, V. Buosi…·X. Meniche

The paper investigates whether protein dynamics after drug binding contribute to kinase inhibitor selectivity by analyzing Aurora A kinase interactions with three drugs.

DOI 10.7554/elife.36656

humanproteomics

𝕏 PostBluesky