Author

V. Buosi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Kern· 2 shared R. Otten· 2 shared A. Zorba· 1 shared C. Wilson· 1 shared D. Swaney· 1 shared D. Theobald· 1 shared G. Kern· 1 shared M. Soucheray· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

D. Kern

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2 papers

Recent·Most cited

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate pool

P. Finneran, M. Soucheray, C. Wilson, R. Otten, V. Buosi, N. J. Krogan, D. Swaney, D. Theobald, D. Kern

This study reveals the bimodal evolution of Src and Abl kinase substrate specificity using mammalian cell extract as a substrate pool, showing divergent evolutionary paths leading to specific and promiscuous enzymes.

bioRxiv · Aug 12, 2020 · PreprintBiochemistry

Dynamics of human protein kinases linked to drug selectivity

D. Kern, W. Pitsawong, V. Buosi, R. Otten, R. V. Agafonov, A. Zorba, N. Kern, S. Kutter, G. Kern, R. A. Padua, X. Meniche

The paper investigates whether protein dynamics after drug binding contribute to kinase inhibitor selectivity by analyzing Aurora A kinase interactions with three drugs.

bioRxiv · Mar 21, 2018Cancer Biology