Author

N. Kern

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

M. A. Morrissey· 2 shared R. D. Vale· 2 shared A. M. Steinbach· 1 shared A. P. Williamson· 1 shared A. Zorba· 1 shared C. B. Carbone· 1 shared D. Kern· 1 shared E. Hui· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

M. A. Morrissey

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Author profile →

4 papers

Recent·Most cited

Tight nanoscale clustering of Fc gamma-receptors using DNA origami promotes phagocytosis

N. Kern, R. Dong, S. M. Douglas, R. D. Vale, M. A. Morrissey

The paper shows that tightly clustering Fc gamma-receptors using DNA origami enhances phagocytosis by increasing receptor phosphorylation and downstream signaling efficiency.

bioRxiv · Mar 18, 2021Cell Biology

Chimeric antigen receptors that trigger phagocytosis

M. A. Morrissey, A. P. Williamson, A. M. Steinbach, E. W. Roberts, N. Kern, M. B. Headley, R. D. Vale

This paper introduces CAR-Ps, chimeric antigen receptors that direct macrophages to engulf specific targets like cancer cells, showing over 40% reduction in cancer cell numbers in co-culture.

bioRxiv · May 16, 2018Cell Biology

Dynamics of human protein kinases linked to drug selectivity

D. Kern, W. Pitsawong, V. Buosi, R. Otten, R. V. Agafonov, A. Zorba, N. Kern, S. Kutter, G. Kern, R. A. Padua, X. Meniche

The paper investigates whether protein dynamics after drug binding contribute to kinase inhibitor selectivity by analyzing Aurora A kinase interactions with three drugs.

bioRxiv · Mar 21, 2018Cancer Biology

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

C. B. Carbone, N. Kern, R. A. Fernandes, E. Hui, X. Su, K. C. Garcia, R. Vale

This paper demonstrates that TCR-pMHC and PD-1-PD-L1 interactions can exclude CD45 from membrane interfaces, creating spatial organization that may regulate T cell signaling.

bioRxiv · Jun 7, 2017Immunology