Author

R. Y.-R. Wang

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Biophysics· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

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C. M. Noddings· 1 shared D. A. Agard· 1 shared

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2020-2020 · peak 1/yr

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1 shared paperBiophysics

C. M. Noddings

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1 paper

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BiophysicsbioRxivSep 12, 2020

GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex

C. M. Noddings, R. Y.-R. Wang, D. A. Agard

This paper reveals the molecular mechanism of GR activation by Hsp90 through cryo-EM, showing GR ligand binding is restored and stabilized by the Hsp90:p23 complex.

DOI 10.1038/s41586-021-04236-1

cryo-EMexperimental assay

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