{Pi}-{Pi} Interactions Stabilize PeptoMicelle-Based Formulations of Pretomanid Derivatives Leading to Promising Therapy Against Tuberculosis in Zebrafish and Mouse Models
N.-J. K. Dal, G. Schafer, A. M. Thompson, S. Schmitt, N. Redinger, N. Alonso-Rodriguez, K. Johann, J. Ojong, J. Wohlmann, A. Best, K. Koynov, R. Zentel, U. E. Shaible, G. Griffiths, M. Barz, F. Fenaroli
This paper develops PeptoMicelle-based formulations of pretomanid derivatives using π-π interactions, showing improved efficacy against tuberculosis in zebrafish and mouse models.
bioRxiv · Mar 10, 2022Bioengineering