S. Schmitt

Using muscle-tendon load limits to assess unphysiological musculoskeletal model deformation and Hill-type muscle parameter choice

This paper assesses musculoskeletal model deformation and Hill-type muscle parameter validity using strain injury metrics in two simulations involving the THUMS AM50 and gait2354 models.

Estimation of contemporary effective population size in plant populations: limitations of genomic datasets

This study evaluates the limitations of genomic datasets in estimating effective population size (Ne) in plants using the GONE software, highlighting issues like missing data, SNP sampling, and chromosomal location information.

High intraspecific growth variability despite strong evolutionary heritage in a neotropical forest

The paper assesses individual tree growth potential in a neotropical forest community over 36 years, finding high intraspecific variation and phylogenetic conservation of growth traits.

{Pi}-{Pi} Interactions Stabilize PeptoMicelle-Based Formulations of Pretomanid Derivatives Leading to Promising Therapy Against Tuberculosis in Zebrafish and Mouse Models

This paper develops PeptoMicelle-based formulations of pretomanid derivatives using π-π interactions, showing improved efficacy against tuberculosis in zebrafish and mouse models.

Somatic mutation detection: a critical evaluation through simulations and reanalyses in oaks

This study evaluates somatic mutation detection in plants using simulations and reanalyses, finding cancer variant callers outperform SNP callers in recall and precision, especially at low allelic fractions.

Real-time respiration changes as a viability indicator for rapid antibiotic susceptibility testing in a microfluidic chamber array

This paper develops a microfluidic platform that measures antibiotic susceptibility by tracking real-time respiration changes in bacterial cultures within 2-3 hours.

MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19

The paper identifies a human-derived monoclonal antibody, MTX-COVAB, with potent neutralizing activity against SARS-CoV-2 in vitro and in a hamster model, showing efficacy against variants and readiness for clinical testing.

Rules of nature's Formula Run: Muscle mechanics during late stance is the key to explaining maximum running speed

This paper proposes a biomechanical model to explain the allometry of maximum legged running speed, identifying muscle inertia as a key factor limiting speed in large animals.

Adaptive mitochondrial regulation of the proteasome

This study shows mitochondrial dysfunction reduces 26S proteasome assembly and activity, which can be reversed by aspartate or pyruvate supplementation.