High-throughput screen using fluorescence lifetime detects compounds that modulate myosin-binding protein C interactions with actin
T. A. Bunch, P. Guhathakurta, V. C. Lepak, A. R. Thompson, R.-S. Kannassatega, A. Wilson, D. D. Thomas, B. A. Colson
This study identifies small-molecule inhibitors of actin-cMyBP-C binding using a fluorescence lifetime assay and validates their mechanism with complementary techniques.
bioRxiv · Mar 24, 2021 · PreprintBiophysics