Author

V. C. Lepak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:fluorescence / live-cell microscopy· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

B. A. Colson· 3 shared T. A. Bunch· 3 shared P. Guhathakurta· 2 shared A. L. Carter· 1 shared A. R. Thompson· 1 shared A. Thompson· 1 shared A. Wilson· 1 shared D. D. D. Thomas· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiophysics

B. A. Colson

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Author profile →

3 papers

Recent·Most cited

Drug discovery for heart failure targeting myosin-binding protein C

T. A. Bunch, P. Guhathakurta, A. Thompson, V. C. Lepak, A. L. Carter, J. J. Thomas, D. D. D. Thomas, B. A. Colson

This study identifies small molecules that modulate cMyBP-C interactions with actin or myosin, aiming to develop therapies for heart failure.

bioRxiv · Apr 3, 2023Biophysics

N-terminal cardiac myosin-binding protein C interactions with myosin and actin filaments using time-resolved FRET

F. L. Wong, T. A. Bunch, V. C. Lepak, B. A. Colson

This study uses TR-FRET to analyze cMyBP-C interactions with myosin and actin, revealing phosphorylation and mutation effects on binding, with implications for HCM therapy.

bioRxiv · Sep 7, 2022 · PreprintBiophysics

High-throughput screen using fluorescence lifetime detects compounds that modulate myosin-binding protein C interactions with actin

T. A. Bunch, P. Guhathakurta, V. C. Lepak, A. R. Thompson, R.-S. Kannassatega, A. Wilson, D. D. Thomas, B. A. Colson

This study identifies small-molecule inhibitors of actin-cMyBP-C binding using a fluorescence lifetime assay and validates their mechanism with complementary techniques.

bioRxiv · Mar 24, 2021 · PreprintBiophysics