Author

P. Guhathakurta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

D. D. Thomas· 3 shared A. L. Carter· 2 shared A. Wilson· 2 shared B. A. Colson· 2 shared T. A. Bunch· 2 shared V. C. Lepak· 2 shared A. E. Atang· 1 shared A. R. Keller· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

D. D. Thomas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Drug discovery for heart failure targeting myosin-binding protein C

T. A. Bunch, P. Guhathakurta, A. Thompson, V. C. Lepak, A. L. Carter, J. J. Thomas, D. D. D. Thomas, B. A. Colson

This study identifies small molecules that modulate cMyBP-C interactions with actin or myosin, aiming to develop therapies for heart failure.

bioRxiv · Apr 3, 2023Biophysics

Identification of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia

P. Guhathakurta, R. T. Rebbeck, S. A. Denha, A. R. Keller, A. L. Carter, A. E. Atang, B. Svensson, D. D. Thomas, T. S. Hays, A. W. Avery

The paper develops an in vitro FRET assay to identify small molecule modulators of the L253P mutant β-III-spectrin actin-binding domain, identifying potential drug candidates for SCA5 treatment.

bioRxiv · Nov 8, 2022 · PreprintBiophysics

High-throughput screen using fluorescence lifetime detects compounds that modulate myosin-binding protein C interactions with actin

T. A. Bunch, P. Guhathakurta, V. C. Lepak, A. R. Thompson, R.-S. Kannassatega, A. Wilson, D. D. Thomas, B. A. Colson

This study identifies small-molecule inhibitors of actin-cMyBP-C binding using a fluorescence lifetime assay and validates their mechanism with complementary techniques.

bioRxiv · Mar 24, 2021 · PreprintBiophysics

Actin-binding compounds, discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle

P. Guhathakurta, L. A. Phung, E. Prochniewicz, S. Lichtenberger, A. Wilson, D. D. Thomas

This study evaluates actin-binding compounds identified through TR-FRET screening, showing differential effects on skeletal and cardiac muscle actin and myofibril function.

bioRxiv · May 19, 2020Biophysics