Structural basis of ligand-selective transcriptional activation in the MerR-family antibiotic resistance regulator AlbA
Michele Di Palma, Alessandro Grinzato, Paolo Andriollo, Leonardo Kleebauer, Marco Leusciatti, G. Morra, R.D. Süssmuth, J. Mark Sutton, Khondaker Miraz Rahman, Roberto A. Steiner
This study reveals how AlbA, an antibiotic resistance regulator, differentially responds to albicidin and PBDs by structurally coupling ligand sensing to transcriptional activation.
bioRxiv · Sep 22, 2026 · PreprintBiochemistry