J. Mark Sutton

This study reveals how AlbA, an antibiotic resistance regulator, differentially responds to albicidin and PBDs by structurally coupling ligand sensing to transcriptional activation.

The paper evaluates caged fluorescent probes for detecting beta-alanine aminopeptidase activity in bacterial species, showing selectivity for Pseudomonas aeruginosa, Burkholderia, and some Serratia strains, while being inactive in others.

The paper develops a semi-automated workflow using cell-free gene expression systems to measure enzymatic activity of antimicrobial resistance genes, showing no difference in results between automated and manual methods.

The paper introduces KlebPhaCol, a resource containing 53 phages and 74 Klebsiella isolates, including a novel gut phage order, to advance understanding of Klebsiella-phage interactions.

This study characterizes the metabolism of Lactobacillus and Gardnerella vaginalis in vaginal defined media, showing differences in lactate production and fermentation strategies compared to complex media.

This study identifies C7-substituted quinolines as potent inhibitors of AdeG efflux pumps in Acinetobacter baumannii, showing significant antibiotic potentiation and selectivity.

This paper constructs a drug hypersensitive Candida auris strain by deleting efflux pump genes, showing it is more effective for antifungal screening than wild-type strains.

The paper identifies mutations in SARS-CoV-2 variants that confer resistance to monoclonal antibodies by analyzing genomic data and validating their impact on antibody neutralization.