Michele Di Palma

Structural basis of ligand-selective transcriptional activation in the MerR-family antibiotic resistance regulator AlbA

This study reveals how AlbA, an antibiotic resistance regulator, differentially responds to albicidin and PBDs by structurally coupling ligand sensing to transcriptional activation.

Continuous Serial Electron Diffraction for High Quality Protein Structures

This paper introduces c-SerialED, a method for high-quality protein structure determination using continuous serial electron diffraction, achieving atomic resolution with reduced radiation damage.

Microtubule architecture connects AMOT stability to YAP/TAZmechanotransduction and Hippo signaling

This study identifies AMOT proteins as a mechanical rheostat linking microtubule architecture to YAP/TAZ mechanotransduction and Hippo signaling.

Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail

This study uses cryo-EM to reveal how microtubule association induces an Mg-free apo-like ADP pre-release conformation in kinesin-1, independent of tail interactions.