Unfolding of the disease-linked bank vole prion protein E200K in the context of PrPSc propagation
Sanaz Sabzehei, Hasier Eraña, Iria Díaz-Arias, Raúl Cacheiro, Arcadio Guerra, Sara María Alvarez-Cardama, Yaiza de León-Vega, Human Rezaei, Joaquı́n Castilla, Víctor M. Sánchez‐Pedregal, Jesús R. Requena, Manuel Martín‐Pastor
This study investigates the early unfolding events of the E200K mutant prion protein in bank voles, comparing it to the wild-type protein to understand its enhanced capacity to generate PrPSc.
bioRxiv · Oct 14, 2026 · PreprintBiochemistry