Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes
Xinchen Chen, Bei Wang, Ankita Sarkar, Zixian Huang, Nicolas Vergara Ruiz, Ann T Yeung, Rachael Chen, Chun Han
This study shows that the Drosophila ABCA protein Eato regulates neurodegeneration by opposing roles in neurons and phagocytes, affecting phagocytosis through suppression of phosphatidylserine signals.
Science Advances · Mar 12, 2025Peer-reviewedNeuroscience