Cortical Parvalbumin-positive Interneuron Development and Function are Altered in the APC Conditional Knockout Mouse Model of Infantile Spasm Syndrome
Rachael F. Ryner, Isabel D. Derera, Moritz Armbruster, Anar Kansara, Mary Sommer, Antonella Pirone, Farzad Noubary, Michele H. Jacob, Chris G. Dulla
This study shows that APC conditional knockout mice exhibit altered parvalbumin-positive interneuron development and inhibitory synaptic dysfunction, contributing to ISS-like phenotypes.
bioRxiv · Jul 6, 2022 · PreprintNeuroscience