Chris G. Dulla

A splice-switching antisense oligonucleotide approach for pediatric genetic epilepsies

This study identifies splice-switching antisense oligonucleotides that correct splicing defects in SCN8A, reducing seizures and improving survival in a mouse model of genetic epilepsy.

iGABASnFR Imaging Reveals Diffusion-Driven GABA Clearance in the Cerebral Cortex

The paper uses a fluorescent GABA sensor to show that GABA diffuses rapidly from release sites and accumulates extracellularly, challenging previous assumptions about GABA clearance mechanisms.

Evidence for the Transient Presence of Atypical Astrocytes in Mice Following a Single, Closed-Head Mild Traumatic Brain Injury

This study shows that a single closed-head mild traumatic brain injury (mTBI) in mice temporarily increases atypical astrocytes (AtAs) but they do not persist long-term, unlike in repeated mTBI.

Glutamate uptake is transiently compromised in the perilesional cortex following controlled cortical impact

This study shows that glutamate uptake is temporarily reduced in the perilesional cortex after TBI, contributing to excitotoxicity, but returns to normal levels by 14 days post-injury.

Cell type-specific gene expression dynamics during human brain maturation

This study uses snRNA-seq and spatial transcriptomics to create a pediatric and adult brain cell atlas, identifying cell type-specific gene expression changes during human brain maturation.

Cortical inhibitory parvalbumin interneurons exhibit metabolic specializations coordinated by PGC-1α that are lost in rodents and humans after traumatic brain injury

The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

This study shows that traumatic brain injury disrupts functional connectivity in mice, with recovery and state-dependent changes in connectivity and theta power during stillness.

Cortical Parvalbumin-positive Interneuron Development and Function are Altered in the APC Conditional Knockout Mouse Model of Infantile Spasm Syndrome

This study shows that APC conditional knockout mice exhibit altered parvalbumin-positive interneuron development and inhibitory synaptic dysfunction, contributing to ISS-like phenotypes.

Neuronal activity drives pathway-specific depolarization of astrocyte distal processes

Genetically encoded voltage imaging reveals presynaptic neuronal activity drives focal astrocyte depolarization, inhibiting glutamate uptake during neuronal activity.

Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake

This study models how fluorescent glutamate indicators affect neurotransmitter diffusion and uptake, showing they delay uptake and reduce extrasynaptic glutamate levels.

Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury

In vivo treatment with 2-deoxyglucose after traumatic brain injury in mice prevented cortical hyperexcitability, synaptic changes, and loss of GABAergic interneurons.

Thresholding of sensory inputs by extrasynaptic glutamate receptors in olfactory bulb glomeruli

The paper demonstrates that extrasynaptic glutamatergic signaling in olfactory bulb glomeruli creates a thresholding effect by balancing excitation and inhibition, allowing only strong stimuli to produce an output.