Moritz Armbruster

This paper uses ratiometric iGluSnFr imaging to measure ambient glutamate levels in brain slices, showing regional differences and transporter sensitivity.

The paper uses a fluorescent GABA sensor to show that GABA diffuses rapidly from release sites and accumulates extracellularly, challenging previous assumptions about GABA clearance mechanisms.

This study shows that a single closed-head mild traumatic brain injury (mTBI) in mice temporarily increases atypical astrocytes (AtAs) but they do not persist long-term, unlike in repeated mTBI.

This study shows that glutamate uptake is temporarily reduced in the perilesional cortex after TBI, contributing to excitotoxicity, but returns to normal levels by 14 days post-injury.

The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.

This study shows that traumatic brain injury disrupts functional connectivity in mice, with recovery and state-dependent changes in connectivity and theta power during stillness.

This study shows that APC conditional knockout mice exhibit altered parvalbumin-positive interneuron development and inhibitory synaptic dysfunction, contributing to ISS-like phenotypes.

Genetically encoded voltage imaging reveals presynaptic neuronal activity drives focal astrocyte depolarization, inhibiting glutamate uptake during neuronal activity.

This study models how fluorescent glutamate indicators affect neurotransmitter diffusion and uptake, showing they delay uptake and reduce extrasynaptic glutamate levels.