USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion
Giulio Collotta, Marco Gatti, Irina-Maria Ungureanu, Vanessa van Ackeren, Emilie Rannou, Francesca Vivalda, Diego Gomez Vieito, Keri M. Fishwick, Christine von Aesch, Antônio Porro, Kyra Ungerleider, Ailin Heidari, Raphaël Guérois, Rachel J Harding, Sylvain Bischof, , Alessandro A. Sartori
This study identifies USP7 as a stabilizer of FAN1, showing its role in DNA crosslink repair and suppression of CAG repeat expansion in Huntington's disease.
Nature Communications · Mar 6, 2026Peer-reviewedMolecular Biology