NGS-RFA/FRA: A High Throughput Experimental and Computational Pipeline for Selective Mutational Scanning in Parallel
Sina Türeli, Theo M. Bestebroer, Sarah James, Rachel Scheuer, Randall Dahn, Shufang Fan, Sam Turner, Sam Wilks, Antonia Netzl, Ana Mosterín, Terry C. Jones, Gabriele Neumann, Yoshihiro Kawaoka, Ron A. M. Fouchier, Mathilde Richard, Derek J. Smith
This paper introduces a high-throughput pipeline for selective mutational scanning in influenza viruses, enabling rapid assessment of variant fitness and escape potential.
bioRxiv · Sep 4, 2026 · PreprintEvolutionary Biology