Yoshihiro Kawaoka

The paper reports a new bat betacoronavirus from Brazil with a functional furin cleavage site in its spike protein, highlighting its phylogenetic distinctiveness and potential zoonotic risk.

This paper introduces a high-throughput pipeline for selective mutational scanning in influenza viruses, enabling rapid assessment of variant fitness and escape potential.

This paper develops a CRISPR-Cas3-based diagnostic platform for emerging RNA viruses, enabling rapid assay design and deployment with high sensitivity and portability.

This study shows bovine-derived H5N1 viruses face evolutionary constraints in ferrets, limiting adaptation for efficient mammalian transmission despite robust replication.

This paper evaluates a low-dose inactivated split virus vaccine against H5N1 influenza, showing cross-protective immunity against multiple clades in a mouse model.

The paper reports the detection of HPAI H5N1 virus RNA in bovine semen from an asymptomatic bull during an outbreak, raising concerns about transmission risks and biosecurity.

This study shows that CR3022-like antibodies can be evolved in vivo through vaccination to neutralize SARS-CoV-2 and related viruses by enhancing affinity and breadth.

This study identifies a conserved DR motif in CDR H3 of antibodies targeting the influenza virus neuraminidase active site, suggesting a common strategy for broad protection.

This study develops a rapid in vitro one-pot plasmid construction method for influenza virus synthesis, reducing plasmid construction time from days to 8 hours with comparable yield and accuracy.

This study shows that influenza A virus uses actomyosin motility for vRNP packaging by blocking myosin activity and observing disrupted vRNP aggregation.

The paper identifies RNA-protein interactomes of SARS-CoV-2 genomic and subgenomic RNAs, revealing new host factors involved in viral replication and antiviral defense.

The paper compares SARS-CoV-2 antigenicity across assays and in human and animal model sera, finding similar immunodominance patterns and antigenic maps but differences in titer magnitude and assay-specific fold change.

The paper identifies host factors critical for influenza virus replication by analyzing network positions of virus-host interactions and validates them through an siRNA screen.