SB 11285, a Novel Canonical Purine-Pyrimidine Cyclic Dinucleotide, is a Systemically Bioavailable STING Agonist for Cancer Immunotherapy
Rupa Challa, Shenghua Zhou, Anjaneyulu Sheri, Geeta Meher, Seetharamaiyer Padmanabhan, Santosh A. Khedkar, Vishal Nair, Rayomand H. Gimi, Dillon C. Cleary, Radhakrishnan P. Iyer
This paper describes the development of SB 11285, a potent and bioavailable STING agonist showing antitumor activity in mouse models and undergoing clinical trials for cancer immunotherapy.
bioRxiv · Mar 27, 2025 · PreprintImmunology