Presymptomatic Targeted Circuit Manipulation for Ameliorating Huntington's Disease Pathogenesis
Ebenezer C Ikefuama, Ashley N. Slaviero, Alexander D. Silvagnoli, Emmanuel L. Crespo, Raegan Schalau, Madison L Gott, Maya O. Tree, Gary Leo Dunbar, Julien Rossignol, Ute Hochgeschwender
The paper investigates presymptomatic manipulation of cortical neuron activity in HD mice to restore E/I balance and slow disease progression.
iScience · Feb 13, 2025Peer-reviewedNeuroscience