Author

Ebenezer C Ikefuama

Central Michigan UniversityORCID 0000-0002-4896-797XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 1

Frequent Co-Authors

Emmanuel L. CrespoiD· 3 shared Ute HochgeschwenderiD· 3 shared Andreas BjörefeldtiD· 2 shared Ashley N. SlavieroiD· 2 shared Christopher I. MooreiD· 2 shared Diane LipscombeiD· 2 shared Gerard G. LambertiD· 2 shared Mansi PrakashiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Emmanuel L. CrespoORCID

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3 papers

Recent·Most cited

Presymptomatic Targeted Circuit Manipulation for Ameliorating Huntington's Disease Pathogenesis

Ebenezer C Ikefuama, Ashley N. Slaviero, Alexander D. Silvagnoli, Emmanuel L. Crespo, Raegan Schalau, Madison L Gott, Maya O. Tree, Gary Leo Dunbar, Julien Rossignol, Ute Hochgeschwender

The paper investigates presymptomatic manipulation of cortical neuron activity in HD mice to restore E/I balance and slow disease progression.

iScience · Feb 13, 2025Peer-reviewedNeuroscience

Engineering luminopsins with improved coupling efficiencies

Ashley N. Slaviero, Nipun Gorantla, Jacob Simkins, Emmanuel L. Crespo, Ebenezer C Ikefuama, Maya O. Tree, Mansi Prakash, Andreas Björefeldt, Lauren M. Barnett, Gerard G. Lambert, Diane Lipscombe, Christopher I. Moore, Nathan C. Shaner, Ute Hochgeschwender

This study evaluates factors affecting luminopsin efficacy and identifies strategies to improve their function through molecular evolution.

Neurophotonics · Mar 29, 2024Peer-reviewedMolecular Biology

A New Highly Efficient Molecule for Both Optogenetic and Chemogenetic Control Driven by FRET Amplification of BioLuminescence

Andreas Björefeldt, Jeremy Murphy, Emmanuel L. Crespo, Gerard G. Lambert, Mansi Prakash, Ebenezer C Ikefuama, Nina G. Friedman, Tariq M. Brown, Diane Lipscombe, Christopher I. Moore, Ute Hochgeschwender, Nathan C. Shaner

The paper introduces a new bioluminescent optogenetic molecule (LMO7) that enhances chemogenetic activation efficacy compared to existing variants, showing improved neuronal activity modulation and behavioral control.

bioRxiv · Jun 26, 2023 · PreprintNeuroscience