A mechanistic model for dynamics between CAR T cells and target cells captures features that determine killing profiles
Suriya Selvarajan, Kevin L. Scrudders, Kenneth Rodriguez-Lopez, Suilan Zheng, Bo Huang, Philip Stewart Low, Raghu Pasupathy, Shalini T. Low-Nam
The paper develops a mechanistic model to predict CAR T cell killing of tumor cells based on contact dynamics and extracts parameters that determine killing efficiency and tumor resilience.
bioRxiv · Jun 24, 2025 · PreprintBiophysics