Author

Philip Stewart Low

Purdue University West LafayetteORCID 0000-0001-9042-5528Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Kenneth Rodriguez-Lopez· 2 shared Kevin L. ScruddersiD· 2 shared Shalini T. Low-NamiD· 2 shared Suilan ZhengiD· 2 shared Suriya Selvarajan· 2 shared Ahmed M. Abdelaal· 1 shared Andrea L. KasinskiiD· 1 shared Andriana Putri· 1 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

Kenneth Rodriguez-Lopez

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeting Macrophage Folate Receptor-β for Diagnosis and Treatment of Autoimmune Myocarditis

Arghavan Jahandideh, Erika Atencio Herre, Wail Nammas, Jenni Virta, Heidi Liljenbäck, Jesse Ponkamo, Andriana Putri, Xiaoqing Zhuang, Johan Rajander, Madduri Srinivasarao, Philip Stewart Low, Yingjuan June Lu, Xiang‐Guo Li, Juhani M. Knuuti, Anne Roivainen, Antti Saraste

This study targets macrophage folate receptor-β in autoimmune myocarditis to reduce macrophage infiltration using a folate-aminopterin conjugate.

bioRxiv · Nov 2, 2025 · PreprintImmunology

CAR T cell cytotoxic responses are rapidly generated and sensitive to the unligated TCR

Kevin L. Scrudders, Suriya Selvarajan, Kenneth Rodriguez-Lopez, Weichuan Luo, Bo Huang, Suilan Zheng, Geoffrey H. Graff, Francisco N. Barrera, Philip Stewart Low, Shalini T. Low-Nam

This study investigates CAR T cell cytotoxic responses, showing they are sensitive to TCR interactions and can be modulated by inhibitory peptides.

bioRxiv · Jul 25, 2025 · PreprintImmunology

A mechanistic model for dynamics between CAR T cells and target cells captures features that determine killing profiles

Suriya Selvarajan, Kevin L. Scrudders, Kenneth Rodriguez-Lopez, Suilan Zheng, Bo Huang, Philip Stewart Low, Raghu Pasupathy, Shalini T. Low-Nam

The paper develops a mechanistic model to predict CAR T cell killing of tumor cells based on contact dynamics and extracts parameters that determine killing efficiency and tumor resilience.

bioRxiv · Jun 24, 2025 · PreprintBiophysics

Enhancing microRNA activity through increased endosomal release mediated by nigericin

Esteban A. Orellana, Ahmed M. Abdelaal, Loganathan Rangasamy, Srinivasarao Tenneti, Sunghyun Myoung, Philip Stewart Low, Andrea L. Kasinski

This paper develops a method to enhance miRNA activity by promoting endosomal escape using nigericin and folate ligands, enabling cytoplasmic delivery and RNAi activation.

Molecular Therapy — Nucleic Acids · Apr 11, 2019Peer-reviewedMolecular Biology