Lipid-mediated regulation of pneumolysin balances vascular injury and bacterial containment during pneumococcal infection
Martina Kiefmann, Sven Hammerschmidt, Alexander Dietrich, Rainer Kiefmann
This study shows that 25-hydroxycholesterol protects against pneumolysin-induced vascular injury, while its suppression allows bacterial containment through coagulation, with PAF acting as a compensatory antagonist.
bioRxiv · Jun 28, 2026 · PreprintImmunology