Phage-encoded homing endonucleases attenuate bacterial immunity
Tridib Mahata, Katarzyna Kanarek, Rameshkumar Marimuthu Ragavan, Anushree Haldar, Guy Shur, Ruba Yehia, David Burstein, Yoni Haitin, Udi Qimron, Dor Salomon
This study shows phage-encoded homing endonucleases reduce bacterial immunity by inhibiting GAPS4, a DNase defense system, thereby enhancing phage fitness.
bioRxiv · Sep 7, 2025 · PreprintMicrobiology