Dor Salomon

Pantoea agglomerans T6SS effectors reside in hotspots with combinatorial offensive and defensive arsenals

The paper maps T6SS effector landscapes in Pantoea agglomerans using proteomics and genomics, revealing dynamic genomic hotspots with offensive and defensive systems.

A-to-I mRNA editing recodes CqsA and affects T6SS-mediated killing in Vibrio

This study identifies A-to-I RNA editing in Vibrio alginolyticus, showing it modifies CqsA to affect T6SS-mediated interbacterial killing.

Vibrio campbellii encodes a distinct set of type III secretion system effectors that mediate cytotoxicity in eukaryotic host models

This study identifies four T3SS-secreted effectors in V. campbellii that exhibit cytotoxicity in eukaryotic cells, highlighting conserved T3SS structure but variable effector repertoires across the Harveyi clade.

Choice of host model and manipulated transcription regulator dictates T6SS effector-mediated toxicity

The paper investigates how host model and transcription regulators influence T6SS effector-mediated toxicity in Vibrio proteolyticus, showing host-dependent effector activation and regulation.

Aeromonas adhesins facilitate kin and non-kin attachment to enable T6SS-mediated antagonism in liquid

This study shows marine bacteria use T6SS to compete in liquid by aggregating via adhesins, challenging the assumption that T6SS activity is limited to solid surfaces.

Phage-encoded homing endonucleases attenuate bacterial immunity

This study shows phage-encoded homing endonucleases reduce bacterial immunity by inhibiting GAPS4, a DNase defense system, thereby enhancing phage fitness.

Assessing toxicity and competitive fitness of vibrios isolated from coastal waters in Israel

The paper assesses the pathogenic potential of Vibrio isolates from Israel's coastal waters, finding toxin diversity, immune cell toxicity, and antibiotic resistance.

WHIX is a T6SS secretion domain found in polymorphic double-edged sword effectors

The paper identifies WHIX as a T6SS secretion domain that enables the delivery of effectors with one or two toxic domains, requiring specific immunity proteins to counteract their toxicity.

Quorum Sensing Regulates Virulence Factors in the Coral Pathogen Vibrio coralliilyticus

This study identifies an active quorum sensing pathway in Vibrio coralliilyticus that regulates virulence factors like proteases, biofilms, and type VI secretion systems.

A T6SS in the coral pathogen Vibrio coralliilyticus secretes an arsenal of anti-eukaryotic effectors and contributes to virulence

This study identifies two temperature-regulated T6SSs in Vibrio coralliilyticus, revealing their roles in bacterial competition and host toxicity, with T6SS2 secreting nine novel anti-eukaryotic toxins.

Bile acids activate the antibacterial T6SS1 in the gut pathogen Vibrio parahaemolyticus

This study shows that secondary bile acids activate T6SS1 in Vibrio parahaemolyticus, enabling it to kill commensal bacteria and enhance its virulence.