Tridib Mahata

The paper maps T6SS effector landscapes in Pantoea agglomerans using proteomics and genomics, revealing dynamic genomic hotspots with offensive and defensive systems.

This study shows phage-encoded homing endonucleases reduce bacterial immunity by inhibiting GAPS4, a DNase defense system, thereby enhancing phage fitness.

The paper describes a method for efficiently engineering phage genomes without using selection or CRISPR-Cas systems, achieving mutation rates of 1-14% for single-base substitutions, deletions, and insertions in three phages.