Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues
Xiao Zhang, Sreejith S. Panicker, Jordan M. Bollinger, Anurag Majumdar, Rami Kheireddine, Lila F. Dabill, Clara T. Kim, Brian A. Kleiboeker, F. Zhang, Yongbin Chen, Kristann L. Magee, Brian S. Learman, Ádám Kepecs, Gretchen A. Meyer, Jun Liu, , Erica L. Scheller
The paper identifies a catecholamine-independent lipolysis pathway activated by hypoglycemia and hypoinsulinemia that enables catabolism of stable adipose tissues.
Nature Metabolism · Jan 8, 2026Peer-reviewedPhysiology