Fengrui Zhang

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency

This study uses reverse genetics in humanized mice to show that DPP9 deficiency causes CARD8-mediated pyroptosis in human hematopoietic stem and progenitor cells, leading to pancytopenia.

T Cell Receptors for Antigen on Intraepitheial Cytolytic T Lymphocytes in Celiac Disease Engage Enterocyte HLA-E and HLA-B

This study identifies IFNγ-producing intraepithelial CTLs in celiac disease that interact with HLA-E/B on enterocytes, promoting CTL recruitment and epithelial killing.

Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues

The paper identifies a catecholamine-independent lipolysis pathway activated by hypoglycemia and hypoinsulinemia that enables catabolism of stable adipose tissues.

FABP5 regulates ether lipid metabolism to ameliorate atopic dermatitis

This study shows FABP5 regulates ether lipid metabolism, reducing inflammation in atopic dermatitis by modulating platelet activating factor levels.