Gretchen A. Meyer

Sustained loss of Pptc7 triggers variable skeletal muscle dysfunction and diminished body mass through dysregulation of BNIP3

This study shows that sustained Pptc7 loss in adult mice causes skeletal muscle dysfunction and reduced body mass through BNIP3 dysregulation, with partial rescue by Bnip3 KO.

Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues

The paper identifies a catecholamine-independent lipolysis pathway activated by hypoglycemia and hypoinsulinemia that enables catabolism of stable adipose tissues.

Markers of mitochondrial function and oxidative metabolism in female skeletal muscle do not display intrinsic circadian regulation

The study shows that mitochondrial function and oxidative metabolism markers in female mouse skeletal muscle lack intrinsic circadian regulation, despite core-clock genes showing rhythmicity.

Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

This study shows that the lysosomal LRRC8 complex regulates lysosomal pH, morphology, and systemic glucose metabolism by affecting mTOR signaling and autophagic flux.

Site-1 Protease is a negative regulator of sarcolipin promoter activity

This study shows that Site-1 Protease (S1P) negatively regulates sarcolipin expression by inhibiting its promoter activity through ATF6 and CREB binding.

Site-1 Protease inhibits mitochondrial metabolism by controlling the TGF-β target gene MSS51

This study identifies Site-1 Protease (S1P) as a negative regulator of muscle mass and mitochondrial metabolism by controlling the TGF-β target gene MSS51.