Author

Ramu Kakumanu

Moffitt Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

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Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Andriy MarusykiD· 1 shared Bina DesaiiD· 1 shared Bruna PelliniiD· 1 shared David BasantaiD· 1 shared Eric B. HauraiD· 1 shared Jhanelle Gray· 1 shared Julia Pelesko· 1 shared Jyllica Aurelio· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Andriy MarusykORCID

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1 paper

Recent·Most cited

Pharmacokinetic Acceleration via CYP3A4 Hyperactivation as a Clinically Actionable Mechanism of Targeted Therapy Resistance in NSCLC

Pragya Kumar, Menkara Henry, Julia Pelesko, Bina Desai, Malgorzata Tyczynska Weh, Ramu Kakumanu, Min Liu, Natália Souza Nunes Siqueira, Robert Vander Velde, Viktoriya Marusyk, Jyllica Aurelio, Eric B. Haura, Jhanelle Gray, Bruna Pellini, David Basanta, Andriy Marusyk

This paper identifies CYP3A4 hyperactivation as a tumor-extrinsic resistance mechanism in NSCLC, showing it reduces drug exposure and leads to resistance, and proposes dosing optimization and CYP3A4 inhibition as solutions.

bioRxiv · May 20, 2026 · PreprintCancer Biology