Min Liu

Neurokinin 1 receptor blockade is associated with increased survival of patients with C. difficile infection

This study shows that blocking the Neurokinin 1 receptor with antagonists improves survival in C. difficile infection patients and reduces vascular inflammation.

A lipid-laden macrophage niche drives immunosuppression in primary central nervous system lymphoma

This study identifies lipid-laden macrophages as an immunosuppressive niche in PCNSL, validated through spatial transcriptomics and mouse models, and shows SYK inhibition reverses their tumor-supportive activity.

TAp63-regulated oncogenic long non-coding RNA-8 ( TROLL-8 ) regulates human breast cancer progression through CPT1A-mediated fatty acid oxidation

This study identifies TROLL-8 as a regulator of fatty acid oxidation in breast cancer, showing its role in promoting tumorigenesis through CPT1A interaction.

Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

The paper identifies the proteomic composition and functional interdependence of the vertebrate C2a projection, showing that loss of any of three proteins causes ciliary dysfunction and primary ciliary dyskinesia in mice.

Pharmacokinetic Acceleration via CYP3A4 Hyperactivation as a Clinically Actionable Mechanism of Targeted Therapy Resistance in NSCLC

This paper identifies CYP3A4 hyperactivation as a tumor-extrinsic resistance mechanism in NSCLC, showing it reduces drug exposure and leads to resistance, and proposes dosing optimization and CYP3A4 inhibition as solutions.

Opposing neural signals of CaV1-encoded peptides are tuned by C-terminus mediated inhibition

The paper identifies opposing transcription signals mediated by CaV1-encoded DCT peptides and shows they are regulated by C-terminus mediated inhibition.