Robert Vander Velde

SupeRJump identifies differentiation fate and discontinuous transitions in leukemia using a semi-supervised jump diffusion model applied to scRNA-seq data.

This paper identifies CYP3A4 hyperactivation as a tumor-extrinsic resistance mechanism in NSCLC, showing it reduces drug exposure and leads to resistance, and proposes dosing optimization and CYP3A4 inhibition as solutions.

The paper shows that targeted therapy resistance in cancer selects for cells with higher phenotypic plasticity, which enhances their ability to adapt to other stressors and promotes metastasis.

CloneSweeper enables multiplexed lineage tracking to identify pre-existing resistant lineages in melanoma, revealing a primed state associated with de-differentiation and inflammatory signaling.

SpaceBar enables clone tracing and spatial transcriptomics profiling by using synthetic barcodes to label cells and analyze gene expression in situ.

This study tracks resistant cancer clones through treatment using single-cell RNA-sequencing and barcoding, showing clones have distinct fates and gene expression states that predict survival.

The paper challenges the classic U-shape model of resistance by proposing alternative population-level models for ruxolitinib resistance in CMML and explores the role of oxygen and cytokine signaling in resistance dynamics.

This paper uses evolutionary game theory to model tumour heterogeneity in glycolysis, angiogenesis, and oxygen availability, showing dynamic regimes and the importance of treatment timing.