Chemically modified CRISPR enzymes for multi-organ genome editing in vivo
Christopher M. Baehr, Alzbeta Ressnerova, Min Hyung Kang, Sheng Zhao, Beatrice Le, Rania F Haddad, Kunica Asija, Mark A. Damante, Rohit Kumar Sharma, Christy A George, Heidi Huang, Dror Assa, Eric A. Noel, Brigette Manohar, Peter Anthony Otero, , Ross C. Wilson
This paper introduces PERCEPT, a CRISPR delivery platform that enables multi-organ genome editing in vivo by chemically modifying CRISPR enzymes for targeted and efficient delivery.
bioRxiv · Sep 16, 2026 · PreprintBioengineering