Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the SNCA gene
Jennifer Modamio, Cláudia Saraiva, Gemma Gomez‐Giro, Sarah Nickels, Javier Jarazo, Paul M. A. Antony, Peter A. Barbuti, Rashi Hadler, Christian Jäger, Rejko Krüger, Enrico Glaab, Jens Christian Schwamborn
This study uses patient-specific midbrain organoids with SNCA triplication to show synaptic decline precedes dopaminergic neuron loss in Parkinson's disease.
bioRxiv · Jul 15, 2021 · PreprintNeuroscience