Javier Jarazo

Replicative senescence of neural progenitors induces astrocyte senescence in 2D cultures and human midbrain organoids

This study uses human iPSC-derived cells to model replicative senescence in neural progenitors and shows it induces astrocyte senescence in 2D cultures and midbrain organoids, linking it to Parkinson's disease.

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a SNCA Triplication

This study uses iPSC-derived neurons and midbrain organoids with SNCA triplication to show autophagy defects correlate with -Synuclein pathology and neuronal loss in Parkinson's disease.

PINK1 regulates cholesterol homeostasis via SCAP phosphorylation in human dopaminergic neurons

This study shows that PINK1 regulates cholesterol homeostasis in human dopaminergic neurons by phosphorylating SCAP, and restoring cholesterol levels rescues defects in neurotransmitter uptake.

Released mitochondrial DNA and neurofilament light chain as Parkinson's disease phenotypes in patient-specific midbrain assembloids

The paper assesses mitochondrial DNA and neurofilament light chain levels in midbrain assembloids to identify Parkinson's disease phenotypes and potential biomarkers.

DJ-1 mediates regulation of metabolism and immune response in Parkinsons disease astrocytes and Glioblastoma cells

This study shows DJ-1 affects metabolism and immune response differently in Parkinson's disease and glioblastoma cells, with antioxidant treatment rescuing PD-related phenotypes.

SARS-CoV-2 infection induces dopaminergic neuronal loss in midbrain organoids during short and prolonged cultures

This study shows SARS-CoV-2 infection causes gene expression changes and dopaminergic neuron loss in midbrain organoids over time.

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.

This study integrates human iPSC-derived microglia into midbrain organoids, enhancing neuronal maturation and functionality through effects on synaptic remodeling and excitability.

Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the SNCA gene

This study uses patient-specific midbrain organoids with SNCA triplication to show synaptic decline precedes dopaminergic neuron loss in Parkinson's disease.

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment

This study shows that HP-β-CD treatment improves dopaminergic differentiation in PD patient-derived midbrain organoids by enhancing mitophagy.