Gemma Gomez‐Giro

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a SNCA Triplication

This study uses iPSC-derived neurons and midbrain organoids with SNCA triplication to show autophagy defects correlate with -Synuclein pathology and neuronal loss in Parkinson's disease.

Released mitochondrial DNA and neurofilament light chain as Parkinson's disease phenotypes in patient-specific midbrain assembloids

The paper assesses mitochondrial DNA and neurofilament light chain levels in midbrain assembloids to identify Parkinson's disease phenotypes and potential biomarkers.

Insulin resistance compromises midbrain organoid neural activity and metabolic efficiency predisposing to Parkinsons disease pathology

This study shows insulin resistance in midbrain organoids reduces metabolic efficiency and neural activity, contributing to Parkinson's disease pathology.

CLN3 deficiency leads to neurological and metabolic perturbations during early development

This study shows that CLN3 deficiency in zebrafish leads to metabolic changes, including GPD accumulation and BMP reduction, and confirms these findings in human stem cell models.

Age-induced midbrain-striatum assembloids model early phenotypes of Parkinsons disease

This paper introduces midbrain-striatum assembloids with inducible aging to model early Parkinson's disease phenotypes and nigrostriatal connectivity.

Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the SNCA gene

This study uses patient-specific midbrain organoids with SNCA triplication to show synaptic decline precedes dopaminergic neuron loss in Parkinson's disease.

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment

This study shows that HP-β-CD treatment improves dopaminergic differentiation in PD patient-derived midbrain organoids by enhancing mitophagy.