PCNA Inhibition Enhances the Antitumor Activity of KRAS-Targeted Therapies in Pancreatic Cancer
Sahar F. Bannoura, Husain Yar Khan, Amro Aboukameel, Yin Wan, Bin Bao, Md. Hafiz Uddin, Hugo Jimenez, Adeeb Aboukameel, Rayyan Siddiqui, Filza Khan, Pouya Haratipour, Long Gu, Rafic Beydoun, M. W. Saif, Miguel E. Tobon, , Asfar S. Azmi
This study shows that combining PCNA inhibitor AOH1996 with KRAS inhibitors enhances antitumor activity in pancreatic cancer models.
bioRxiv · Dec 10, 2025 · PreprintCancer Biology