Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice
Hyung-Seok Kim, Mary L Sanchez, Joshua Silva, Heidi Schubert, Rebecca Dennis, Christopher P. Hill, Jan L. Christian
This study shows that mutations preventing phosphorylation of BMP4's prodomain impair its proteolytic activation in homodimers, causing lethality in mice.
bioRxiv · Oct 8, 2024Cell Biology