Hyung-Seok Kim

Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice

This study shows that mutations preventing phosphorylation of BMP4's prodomain impair its proteolytic activation in homodimers, causing lethality in mice.

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis

This study shows that BMP7 functions mainly as a heterodimer with BMP2 or BMP4 during mammalian development, as demonstrated by genetic experiments and co-immunoprecipitation assays.